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our paper on Rheumatoid Arthritis modeling is out

4/17/2017

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Our lab's long-standing collaboration with the group of George Kollias at the Biomedical Sciences Research Center "Alexander Fleming" is bearing fresh fruit in our latest publication that came out last week at Arthritis and Rheumatology. 
The paper titled "Genomic responses of mouse synovial fibroblasts during TNF-driven arthritogenesis greatly mimic those of human rheumatoid arthritis" is the result of a couple of years of efforts with colleagues and friends Evangelos Ntougkos and Panagiotis Chouvardas to analyze the arthritogenic potential of synovial fibroblasts in a transgenic mouse model of Rheumatoid Arthritis. It is a work that took a long (perhaps too long) time to come out and which is (in my view) not over yet as a number of questions remain to be answered from the copious amounts of data we have gathered. For those of you who are too bored or too busy to go through the paper beforehand you can take a look at its editorial commentary, in which Ulf Muller-Lander and Elena Neumann give a concise but short summary of our findings and close with a rather intriguing comment on our bioinformatics work saying that:

"Taken together, the paper shows nicely that the large scale puzzle RA cannot be solved by pouring millions of highly variable fragments into a high-end bioinformatics computer but only piece by piece by innovative scientists with careful evaluation of hypothesis-driven data sets."

I will be covering this last comment and a number of questions that are cracked open by our work in an upcoming post on our CG2 blog. 
(For the time being I am off to grade some grad papers)
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New paper by CG2

4/7/2017

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 Our lab's latest publication is a collaboration with the group of Niki Kretsovali at the IMBB, FORTH. Appearing in Stem Cell Reports, this work by lead author and friend Christiana Hadjimichael shows that Promyelocytic Leukemia Protein (PML) is a key factor in the maintenance of pluripotency in mouse ES cells, exhibiting its control on a number of pathways including that of TGF-β at an early stage. Antonis Klonizakis, an undergraduate student from our group, was involved in the analysis of public gene expression datasets to show that PML knockdown cells resemble a state of primed differentiation, lying intermediate between ES and epiblast cells. Besides the main finding behind it, this work was, from our part, a manifestation of the inherent difficulties in assessing published results in view of their heterogeneity, the lack of sufficient reporting and standardization, all of which are issues that need to be addressed yesterday in want of a more efficient way of accumulating knowledge instead of simply piling up information. Stay tuned for a blog post on this (and other matters).
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