A recent work of the group on how chromatin structure affects gene expression was published in this month's issue of Nucleic Acids Research. The paper, a collaboration with Joaquim Roca of the Barcelona Scientific Park shows how distinct chromatin structures at the promoters of yeast genes may shape the gene expression susceptibility upon topo-isomerase II inactivation. In this sense, a link is drawn between chromatin structure (and nucleosome positioning in particular) with the local topological strains imposed by the absence of topo-isomerase II.
In a nutshell, the effect of topological stresses that are not resolved by topoisomerases are also dependent on the underlying sequence and 3D structure of the promoter region.
Read more online here and check out the group's publications page.
In a nutshell, the effect of topological stresses that are not resolved by topoisomerases are also dependent on the underlying sequence and 3D structure of the promoter region.
Read more online here and check out the group's publications page.